Advanced search×

Differential regulation of interleukin 17 and interferon production in inflammatory bowel disease

Gut 58(12):1629-1636 (2009) PMID 19740775

Interleukin 17 (IL17) is now known to be involved in a number of chronic inflammatory disorders. However, the mechanisms regulating its production in inflammatory bowel disease (IBD) are still unclear.

DOI: 10.1136/gut.2009.182170
Version: za2963e q8za2 q8zb2 q8zc1 q8zd9 q8ze6 q8zf6 q8zg9

Similar articles you may find interesting…

  1. Roles of T helper 17 cells and interleukin-17 in neuroautoimmune diseases with emphasis on multiple sclerosis and Guillain-Barré syndrome as...

    J Neurosci Res (2013) PMID 23653308

    The identification of T helper 17 (Th17) cells challenges the Th1/Th2 paradigm of the immune response and invites intensive exploration of their mechanisms and functions in the field of autoimmune diseases, host defense, allergy, etc. The collective data have shown that transforming...
  2. Identification of Host Proteins Involved in Japanese Encephalitis Virus Infection by Quantitative Proteomics Analysis.

    J Proteome Res (2013) PMID 23647205

    We performed a SILAC-based quantitative proteomics study of JEV-infected HeLa cells using a subcellular fractionation strategy. We identified 158 host proteins as differentially regulated by JEV (defined as exhibiting a greater than 1.5-fold change in protein abundance upon JEV infection). The mass...
  3. Mechanism of endogenous regulation of the type I interferon response by Suppressor of IKK{epsilon} (SIKE), a novel substrate of TANK binding...

    J Biol Chem (2013) PMID 23649622

    We describe the mechanism by which Suppressor of IKKε (SIKE) inhibits TBK1-mediated phosphorylation of interferon regulatory factor 3 (IRF3), essential to type I interferon production. Kinetic analyses showed that SIKE not only inhibits IRF3 phosphorylation, but is also a high-affinity, TBK1 substr...