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A versatile approach for assaying in vitro metallodrug metabolism using CE hyphenated with ICP-MS.

Jan K JK Abramski, Lidia S LS Foteeva, Kasia K Pawlak, Andrei R AR Timerbaev, and Maciej M Jarosz

Analyst 134(10):1999-2002 (2009) PMID 19768206

An informative analytical method, based on commercially available capillary electrophoresis (CE), inductively coupled plasma mass spectrometry (ICP-MS) and interface units, was developed for ascertaining possible metabolic transformations of metal-based drugs. Using a novel anticancer gallium compound, it was demonstrated that the drug remains intact in the simulated intestine juice. On the contrary, it undergoes a marked change in speciation (mostly, due to binding to transferrin) in human serum.

DOI: 10.1039/b913954k
Version: za2963e q8za0 q8zbf q8zc2 q8zd8 q8zec q8zfd q8zge
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