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Live attenuated vaccines for pandemic influenza.

Grace L Chen and Kanta Subbarao

Curr Top Microbiol Immunol (2009) PMID 19768402

In this chapter, we will review the development of and clinical experience with the currently licensed seasonal live attenuated influenza vaccines (LAIV) and preclinical studies of H5, H7, and H9 live attenuated pandemic influenza vaccine candidates. Vectored vaccine approaches will not be reviewed in this chapter. Experience with seasonal influenza vaccination has demonstrated the safety and efficacy of LAIV in both children and adults; moreover, cross-protection among antigenically distinct viruses within the same subtype may be induced by LAIV. While clinical studies and further characterization of the immunologic response to avian influenza viruses are still needed, the experience with seasonal LAIV underscores the potential of live attenuated vaccines to play an important role in the event of a pandemic.

DOI: 10.1007/978-3-540-92165-3_5
Version: za2963e q8za3 q8zbd q8zc7 q8zdc q8ze5 q8zfd q8zg8
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