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Animal Models of Anemia of Inflammation

Seth Rivera and Tomas Ganz

Semin Hematol 46(4):7 (2009) PMID 19786203

Anemia of inflammation (AI) is a complex multi-organ response to inflammatory disorders. Because AI can result from many infectious and non-infectious inflammatory diseases, multiple mechanisms may contribute to its pathogenesis, including iron restriction, direct erythropoietic suppression, shortened red blood cell survival, and frank hemolysis. Animal models have been helpful in the study of the mechanisms of AI and its potential treatments, but each model reflects distinct aspects of this heterogeneous syndrome. It is therefore important to study a variety of models of AI. This review focuses on the use of infectious and noninfectious mouse models of inflammation that have been shown to manifest anemia. We review many of the models reported in the literature or developed in our laboratory, and discuss their respective merits and drawbacks.

Copyright © 2009 Elsevier Ltd. All rights reserved.

DOI: 10.1053/j.seminhematol.2009.06.003
Version: za2963e q8za4 q8zb1 q8zcf q8zd1 q8ze4 q8zf8 q8zgd
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