Anemia of inflammation (AI) is a complex multi-organ response to inflammatory disorders. Because AI can result from many infectious and non-infectious inflammatory diseases, multiple mechanisms may contribute to its pathogenesis, including iron restriction, direct erythropoietic suppression, shortened red blood cell survival, and frank hemolysis. Animal models have been helpful in the study of the mechanisms of AI and its potential treatments, but each model reflects distinct aspects of this heterogeneous syndrome. It is therefore important to study a variety of models of AI. This review focuses on the use of infectious and noninfectious mouse models of inflammation that have been shown to manifest anemia. We review many of the models reported in the literature or developed in our laboratory, and discuss their respective merits and drawbacks.
We demonstrate the presence of RSV proteins and RNA in zones of the brain-such as the hippocampus, ventromedial hypothalamic nucleus, and brainstem-of infected mice. One month after disease resolution, rodents showed behavioral and cognitive impairment in marble burying (MB) and Morris water maze (M...
The ALICE Collaboration at the LHC has measured the j/psi and psi'
photoproduction at mid-rapidity in ultra-peripheral Pb-Pb collisions at
sqrt(sNN) = 2.76 TeV. The charmonium is identified via its leptonic decay for
events where the hadronic activity is required to be minimal. The analysis is
An earlier measurement on the 4$^+$ to 2$^+$ radiative transition in $^8$Be
provided the first electromagnetic signature of its dumbbell-like shape.
However, the large uncertainty in the measured cross section does not allow a
stringent test of nuclear structure models. The present paper reports a...
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