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Consensus Statement on Diagnostic Criteria for PHACE Syndrome.

Denise D Metry, Geoffrey G Heyer, Christopher C Hess, Maria M Garzon, Anita A Haggstrom, Peter P Frommelt, Denise D Adams, Dawn D Siegel, Karla K Hall, Julie J Powell, Ilona I Frieden, Beth B Drolet, and

Pediatrics 124(5):1447-56 (2009) PMID 19858157

A subgroup of patients with infantile hemangiomas have associated structural anomalies of the brain, cerebral vasculature, eyes, sternum, and/or aorta in the neurocutaneous disorder known as PHACE syndrome. The diagnosis has been broadly inclusive by using a case definition of a facial hemangioma plus >or=1 extracutaneous features, leading to numerous reports of potential associated disease features, many of uncertain significance. This consensus statement was thus developed to establish diagnostic criteria for PHACE syndrome.

DOI: 10.1542/peds.2009-0082
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