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Biologic activities of the TolC-like protein of Neisseria meningitidis as assessed by functional complementation in Escherichia coli.

Nazia N Kamal and William M WM Shafer

Audio, Transactions of the IRE Professiona... 54(1):506-8 (2010) PMID 19884363 PMCID PMC2798496

Neisseria meningitidis can produce a TolC-like protein needed for secretion of FrpC but not efflux of antimicrobials. We now report that expression of the meningococcal tolC gene in a TolC-deficient strain of Escherichia coli can restore properties of alpha-hemolysis and antimicrobial resistance known to involve efflux pumps.

DOI: 10.1128/AAC.01168-09
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