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A method for correlating in vivo prostate magnetic resonance imaging and histopathology using individualized magnetic resonance-based molds.

Vijay V Shah, Thomas T Pohida, Baris B Turkbey, Haresh H Mani, Maria M Merino, Peter A PA Pinto, Peter P Choyke, and Marcelino M Bernardo

Rev Sci Instrum 80(10):104301 (2009) PMID 19895076

A method for the design and rapid manufacture of a patient specific tissue slicing device based on in vivo images in order to facilitate the process of correlating the images with histopathology is presented. The method is applied to radical prostatectomy specimens where the customized mold is designed using magnetic resonance (MR) images of each patient obtained prior to surgery. In this case, the mold holds the prostate in place while a knife with a single blade or multiple blades is inserted in slots which are positioned to obtain tissue blocks corresponding to the slices in the MR images. The resulting histological specimens demonstrate good anatomical correlation with the MR images.

DOI: 10.1063/1.3242697
Version: za2963e q8za4 q8zb3 q8zcc q8zd1 q8ze4 q8zfc q8zg7

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