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Status epilepticus affects the gigantocellular network of the pontine reticular formation.

Péter Baracskay, Viola Kiglics, Katalin A Kékesi, Gábor Juhász, and András Czurkó

BMC Neurosci (2009) PMID 19912649

The impairment of the pontine reticular formation (PRF) has recently been revealed to be histopathologically connected with focal-cortical seizure induced generalized convulsive status epilepticus. To elucidate whether the impairment of the PRF is a general phenomenon during status epilepticus, the focal-cortical 4-aminopyridine (4-AP) application was compared with other epilepsy models. The presence of "dark" neurons in the PRF was investigated by the sensitive silver method of Gallyas in rats sacrificed at 3 h after focal 4-AP crystal or systemic 4-AP, pilocarpine, or kainic acid application. The behavioral signs of the developing epileptic seizures were scored in all rats. The EEG activity was recorded in eight rats.

DOI: 10.1186/1471-2202-10-133
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