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A changing world for DCvax: a PSMA loaded autologous dendritic cell vaccine for prostate cancer

Mayer Fishman

Expert Opin Biol Ther 9(12):1565-1575 (2009) PMID 19916735

Northwest Therapeutics' DCvax-prostate consists of autologous dendritic cells (DCs) loaded with prostate-specific membrane antigen (PSMA) peptides, administered intravenously. Phase I-II testing, a decade ago, showed clinical benefit and immunological response in some patients. More recently DCvax brain, a product using a similar DC platform showed encouraging Phase I-II results and sipleucel-T, a prostatic acid phosphatase (PAP)-directed DC immunotherapy had positive Phase III results.

DOI: 10.1517/14712590903446921
Version: za2963e q8za3 q8zbf q8zc4 q8zd2 q8ze3 q8zf7 q8zgb

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