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Micafungin concentrations from brain tissue and pancreatic pseudocyst fluid.

Asma Lat, George R Thompson, Michael G Rinaldi, Sheryl A Dorsey, Gennethel Pennick, and James S Lewis

Antimicrob Agents Chemother 54(2):943-4 (2010) PMID 19933794

We report the attainment of micafungin concentrations from brain tissue and pancreatic pseudocyst fluid from two patients with invasive candidiasis. Micafungin was present in low levels at both body sites, indicating limited penetration into central nervous system (CNS) tissue and pancreatic fluid. Further studies are needed to fully characterize its pharmacokinetics at these locations, as micafungin may potentially serve as an alternative antifungal therapy for CNS or pancreatic candidal infections for which the currently recommended first-line therapy fails.

DOI: 10.1128/AAC.01294-09
Version: za2963e q8za7 q8zb2 q8zc4 q8zd0 q8ze2 q8zf8 q8zg9

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