Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.
The peptidyl prolyl cis/trans isomerase Pin1 is a promising molecular target for anti-cancer therapeutics. Here we report the structure-guided evolution of an indole 2-carboxylic acid fragment hit into a series of alpha-benzimidazolyl-substituted amino acids. Examples inhibited Pin1 activity with IC(50)
Version: za2963e q8za8 q8zbb q8zc6 q8zd2 q8zed q8zf5 q8zgf