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Optimising intraperitoneal gentamicin dosing in peritoneal dialysis patients with peritonitis (GIPD) study.

Dwarakanathan Ranganathan, Julie M Varghese, Robert G Fassett, Jeffrey Lipman, Vincent D'Intini, Helen Healy, and Jason A Roberts

BMC Nephrol (2009) PMID 20003546

Antibiotics are preferentially delivered via the peritoneal route to treat peritonitis, a major complication of peritoneal dialysis (PD), so that maximal concentrations are delivered at the site of infection. However, drugs administered intraperitoneally can be absorbed into the systemic circulation. Drugs excreted by the kidneys accumulate in PD patients, increasing the risk of toxicity. The aim of this study is to examine a model of gentamicin pharmacokinetics and to develop an intraperitoneal drug dosing regime that maximises bacterial killing and minimises toxicity.

DOI: 10.1186/1471-2369-10-42
Version: za2963e q8zac q8zbe q8zca q8zd1 q8zec q8zfc q8zg2
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