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A reprogrammable mouse strain from gene-targeted embryonic stem cells.

Matthias M Stadtfeld, Nimet N Maherali, Marti M Borkent, and Konrad K Hochedlinger

Audio, Transactions of the IRE Professional ... 7(1):53-5 (2010) PMID 20010832

The derivation of induced pluripotent stem cells (iPSCs) usually involves the viral introduction of reprogramming factors into somatic cells. Here we used gene targeting to generate a mouse strain with a single copy of an inducible, polycistronic reprogramming cassette, allowing for the induction of pluripotency in various somatic cell types. As these 'reprogrammable mice' can be easily bred, they are a useful tool to study the mechanisms underlying cellular reprogramming.

DOI: 10.1038/nmeth.1409
Version: za2963e q8za3 q8zb2 q8zc4 q8zd5 q8ze6 q8zf1 q8zg9
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