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RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans.

Paola P Sebastiani, Monty M Montano, Annibale A Puca, Nadia N Solovieff, Toshio T Kojima, Meng C MC Wang, Efthymia E Melista, Micah M Meltzer, Sylvia E J SE Fischer, Stacy S Andersen, Stephen H SH Hartley, Amanda A Sedgewick, Yasumichi Y Arai, Aviv A Bergman, Nir N Barzilai, Dellara F DF Terry, Alberto A Riva, Chiara Viviani CV Anselmi, Alberto A Malovini, Aya A Kitamoto, Motoji M Sawabe, Tomio T Arai, Yasuyuki Y Gondo, Martin H MH Steinberg, Nobuyoshi N Hirose, Gil G Atzmon, Gary G Ruvkun, Clinton T CT Baldwin, and Thomas T TT Perls

PLoS One 4(12):e8210 (2009) PMID 20011587

The strong familiality of living to extreme ages suggests that human longevity is genetically regulated. The majority of genes found thus far to be associated with longevity primarily function in lipoprotein metabolism and insulin/IGF-1 signaling. There are likely many more genetic modifiers of human longevity that remain to be discovered.

DOI: 10.1371/journal.pone.0008210
Version: za2963e q8zab q8zb9 q8zc0 q8zd0 q8ze9 q8zf2 q8zg8
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