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Concurrent chemoradiation followed by adjuvant chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma in Korea.

Kyong Hwa Park, Jeong Sun Kim, Yong Park, Hee Yeon Seo, Young Je Park, In Keun Choi, Sang Chul Oh, Jae Hong Seo, Chul Yong Kim, Kwang Yoon Jung, Sang Won Shin, Yeul Hong Kim, Jun Suk Kim, and Nam Joon Lee

Cancer Chemother Pharmacol 66(4):643-51 (2010) PMID 20033411

Concomitant approach using cisplatin and 5-fluorouracil (5-FU) has shown an excellent local control rate and significantly reduced distant metastasis in patients with locally advanced nasopharyngeal carcinoma (NPC). However, optimal schedule and dosing of chemotherapy still need to be developed to reduce distant metastasis. This retrospective study was conducted to evaluate the efficacy, toxicity, and tolerability of a concurrent chemoradiation therapy (CCRT) regimen using cisplatin and 5-FU followed by adjuvant chemotherapy (AC) in patients with locoregionally advanced NPC.

DOI: 10.1007/s00280-009-1203-6
Version: za2963e q8zad q8zb1 q8zc4 q8zd3 q8zeb q8zfc q8zg8

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