BACKGROUND: Inhaled corticosteroids (ICS) are the mainstay of asthma treatment, but conventional ICS may have limited effectiveness in inflammation and patency of small airways. Ciclesonide is delivered and deposited in the peripheral region of the lung as a small particle corticosteroid. The aim of the study is to compare the effects of ciclesonide with fluticasone propionate on small airway function in asthma. METHODS: Thirty mild persistent asthma patients treated with 200 microg of fluticasone propionate were randomized to receive either ciclesonide 200 microg once daily or fluticasone propionate 100 microg twice daily for 8 weeks. Small airway function was assessed by impulse oscillometry (IOS) and percentage of eosinophil induced sputum. RESULTS: We observed that ciclesonide significantly improved IOS measured resistance of small airways (R5-R20; p<0.01) compared with fluticasone propionate. There were no significant changes in spirometry indices in either group during the study. CONCLUSIONS: These findings suggest that ciclesonide improves small airway function and inflammation compared with fluticasone propionate in mild asthma. This study provides evidence that IOS and late-phase induced sputum allows detection of changes in the small airways that can not be detected by spirometry.
We reviewed the medical records of 9,748 residents of the Worcester, MA, metropolitan area who were hospitalized with ADHF at all 11 central Massachusetts medical centers in 1995, 2000, 2002, and 2004.
Between 1995 and 2004, respectively, the prescription upon hospital discharge of b...
Pregnancy-induced rhinitis (PIR) is often misclassified and under-diagnosed. There is currently no cure or opti- mum symptomatic treatment.
To summarize current knowledge of PIR and assess evidence supporting treatment options.
Structured literature se...
We adopt this information as the metallicity and age of the supernova
Progenitor, under the assumption that it was coeval with the parent stellar
Population. The age of the star corresponds to its lifetime, which in turn
Gives the estimate of its initial mass. With this method we were able to
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