Advanced search×

ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis.

Arthritis Rheum 62(1):171-8 (2010) PMID 20039431

To assess the therapeutic potential of anti-CD3 monoclonal antibodies (mAb) for rheumatoid arthritis, using collagen-induced arthritis as an animal model.

Referenced by 1 articles

DOI: 10.1002/art.25058
Version: za2963e q8zae q8zb3 q8zc9 q8zd8 q8zec q8zf4 q8zg5

Similar articles you may find interesting…

  1. Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome.

    Arthritis Rheum 60(2):619-25 (2009) PMID 19180495

    Unlike findings in controls, cells from a family of 9 patients, all of whom carried the T50M mutation in TNFRSF1A, failed to respond to infliximab through proapoptotic induction of caspase 3 activity. Instead, we observed enhanced antiapoptotic c-Rel subunit activity, accompanied by a significant in...
  2. Lessons from anti-TNF biologics: infliximab failure in a TRAPS family with the T50M mutation in TNFRSF1A.

    Adv Exp Med Biol (2011) PMID 21153346

  3. IFN-{gamma} produced by CD8 T cells induces T-bet-dependent and -independent class switching in B cells in responses to alum-precipitated pr...

    Audio, Transactions of the IRE Profess... 107(40):17292-7 (2010) PMID 20855629

    We now report that CD8 T cells also respond to alum proteins, proliferating extensively and producing IFN-γ, a key Th1 cytokine. These findings led us to question whether adoptive transfer of antigen-specific CD8 T cells alters the characteristic CD4 Th2 response to alum proteins and the switching...