Advanced search×

Modeling of glutamate-induced dynamical patterns.

N C K NC Bentzen, A M AM Zhabotinsky, and J L JL Laugesen

Int J Neural Syst 19(6):395-407 (2009) PMID 20039463

Based on established physiological mechanisms, the paper presents a detailed computer model, which supports the hypothesis that temporal lobe epilepsy may be caused by failure of glutamate reuptake from the extracellular space. The elevated glutamate concentration causes an increased activation of NMDA receptors in pyramidal neurons, which in turn leads to neuronal dynamics that is qualitatively identical to epileptiform activity. We identify by chaos analysis a surprising possibility that muscarinergic receptors can help the system out of a chaotic regime.

Version: za2963e q8za4 q8zb3 q8zc1 q8zdb q8zee q8zf4 q8zgf

Similar articles you may find interesting…

  1. Multi-component reactions in heterocyclic chemistry.
    Maxim A Mironov, Thomas J J Müller, ... M I Vahrin

    Adv Exp Med Biol (2011) PMID 20976584

  2. Bioactive natural products and chirality.
    Kenji K Mori

    Chirality 23(6):449-62 (2011) PMID 21633977

    Mori's synthetic works on bioactive natural products in general and pheromones in particular started about 40 years ago to establish their absolute configurations and also to clarify their stereochemistry-bioactivity relationships. Results indicate that bioactive natural products are...
  3. On the use of collinear and triangle equation for automatic segmentation and boundary detection of cardiac cavity images.
    Riyanto R Sigit, Mohd Marzuki MM Mustafa, ... Ika Faizura Mohd IF Nor

    Adv Exp Med Biol (2011) PMID 21431588

    In this chapter, the computational biology of cardiac cavity images is proposed. The method uses collinear and triangle equation algorithms to detect and reconstruct the boundary of the cardiac cavity. The first step involves high boost filter to enhance the high frequency component without affecting...