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The implications of patterns in HIV diversity for neutralizing antibody induction and susceptibility.

Bette Korber and S Gnanakaran

Curr Opin HIV AIDS 4(5):408-17 (2009) PMID 20048705

Designing an HIV vaccine capable of eliciting broadly cross-reactive neutralizing antibodies is an extraordinarily difficult challenge. Here we focus on the implications of HIV diversity for vaccine design, detailing the impact of levels of variation in epitopes of known potent neutralizing antibodies, and summarizing patterns of overall variation in regional domains within gp120. Strategies for rational vaccine design, to enhance coverage of HIV's natural diversity, are considered.

DOI: 10.1097/COH.0b013e32832f129e
Version: za2963e q8za2 q8zb5 q8zc7 q8zd6 q8ze9 q8zfb q8zg1

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