Advanced search×

The implications of patterns in HIV diversity for neutralizing antibody induction and susceptibility.

Curr Opin HIV AIDS 4(5):408-17 (2009) PMID 20048705

Designing an HIV vaccine capable of eliciting broadly cross-reactive neutralizing antibodies is an extraordinarily difficult challenge. Here we focus on the implications of HIV diversity for vaccine design, detailing the impact of levels of variation in epitopes of known potent neutralizing antibodies, and summarizing patterns of overall variation in regional domains within gp120. Strategies for rational vaccine design, to enhance coverage of HIV's natural diversity, are considered.

DOI: 10.1097/COH.0b013e32832f129e
Version: za2963e q8za2 q8zb5 q8zc7 q8zd6 q8ze9 q8zfb q8zg1

Similar articles you may find interesting…

  1. Molecular definition of the pro-tumorigenic phenotype of glioma-activated microglia.

    Glia (2013) PMID 23650109

    We demonstrate that microglia adapt different fates and polarize into pro-inflammatory or alternatively activated cells. Glioma-derived factors increased cell motility, phagocytosis, and sustained proliferation of microglial cells that was mediated by enhanced focal adhesion kinase and PI-3K/Akt sig...
  2. Depletion and dysfunction of Vγ2Vδ2 T cells in HIV disease: mechanisms, impacts and therapeutic implications.

    Cell Mol Immunol 10(3):283 (2013) PMID 23645299

  3. Genome-wide comparative diversity uncovers multiple targets of selection for improvement in hexaploid wheat landraces and cultivars.

    Proc Natl Acad Sci U S A (2013) PMID 23630259

    We developed a high-throughput array to interrogate 9,000 gene-associated single-nucleotide polymorphisms (SNP) in a worldwide sample of 2,994 accessions of hexaploid wheat including landraces and modern cultivars. Using a SNP-based diversity map we characterized the impact of crop improvement on ge...