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Two-stage capture employing active transport enables sensitive and fast biosensors.

Parag P Katira and Henry H Hess

Nano Lett 10(2):567-72 (2010) PMID 20055432

Nanoscale sensors enable the detection of analytes with improved signal-to-noise ratio but suffer from mass transport limitations. Molecular shuttles, assembled from, e.g., antibody-functionalized microtubules and kinesin motor proteins, can selectively capture analytes from solution and deliver the analytes to a sensor patch. This two-stage process can accelerate mass transport to nanoscale biosensors and facilitate the rapid detection of analytes. Here, the possible increase of the signal-to-noise ratio is calculated, and the optimal layout of a system which integrates active transport is determined.

DOI: 10.1021/nl903468p
Version: za2963e q8zaf q8zbb q8zc5 q8zdc q8zec q8zf8 q8zgc
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