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The B-VITAGE trial: a randomized trial of homocysteine lowering treatment of depression in later life.

Andrew H Ford, Leon Flicker, Kieran McCaul, Frank van Bockxmeer, Sarah Hegarty, Varsha Hirani, Stephen Fenner, and Osvaldo P Almeida

Trials (2010) PMID 20096138

Depression is a leading cause of disability worldwide and depressive symptoms are common in later life. Observational evidence suggests that depression is more prevalent among people with high plasma homocysteine (tHcy), but the results of randomized trials to date have been unable to show that lowering tHcy through the supplementation of vitamins B6, B12 and folate benefits depressive symptoms. We designed the B-VITAGE trial to determine whether adjunctive treatment with vitamins B6, B12 and folate increases the efficacy of standard antidepressant treatment.

DOI: 10.1186/1745-6215-11-8
Version: za2963e q8zae q8zb4 q8zc6 q8zd7 q8ze1 q8zf2 q8zg3
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