Advanced search×

Do COMT, BDNF and NRG1 polymorphisms influence P50 sensory gating in psychosis?

M Shaikh, M-H Hall, K Schulze, A Dutt, M Walshe, I Williams, M Constante, M Picchioni, T Toulopoulou, D Collier, F Rijsdijk, J Powell, M Arranz, R M Murray, and E Bramon

Psychol Med 41(2):263-76 (2011) PMID 20102668

Auditory P50 sensory gating deficits correlate with genetic risk for schizophrenia and constitute a plausible endophenotype for the disease. The well-supported role of catechol-O-methyltransferase (COMT), brain-derived neurotrophic factor (BDNF) and neuregulin 1 (NRG1) genes in neurodevelopment and cognition make a strong theoretical case for their influence on the P50 endophenotype.

DOI: 10.1017/S003329170999239X
Version: za2963e q8za3 q8zb5 q8zc9 q8zdd q8zec q8zfb q8zgb

Similar articles you may find interesting…

  1. The relation of regional cerebral perfusion and atrophy in mild cognitive impairment (MCI) and early Alzheimer's dementia
    Christian C Luckhaus, Mathias M Cohnen, ... Hans-Jörg HJ Wittsack

    Psychiatry Research 183(1):8 (2010) PMID 20541374

    The spatial and temporal relations between regional cerebral blood flow (rCBF) and brain volume (rVOL) changes in incipient and early Alzheimer's dementia (AD) are not fully understood. The participants comprised 30 subjects with mild cognitive impairment (MCI) and 15 with mild AD who were examined...
  2. Association of the NRG1 gene and schizophrenia: a meta-analysis.
    M R MR Munafò, D L DL Thiselton, ... J J Flint

    Mol Psychiatry 11(6):539-46 (2006) PMID 16520822

    We investigated the association of the NRG1 gene and schizophrenia using meta-analytic techniques, combining all published data while restricting our analysis to studies investigating the most commonly reported single marker (SNP8NRG221533). We also investigated whether ancestry (European vs East As...
  3. Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.
    Lin L Mei and Wen-Cheng WC Xiong

    Nat Rev Neurosci 9(6):437-52 (2008) PMID 18478032 PMCID PMC2682371

    Schizophrenia is a highly debilitating mental disorder that affects approximately 1% of the general population, yet it continues to be poorly understood. Recent studies have identified variations in several genes that are associated with this disorder in diverse populations, including those that enc...
    View PDF