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Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families.

David C DC Glahn, Laura L Almasy, Marcela M Barguil, Elizabeth E Hare, Juan Manuel JM Peralta, Jack W JW Kent, Albana A Dassori, Javier J Contreras, Adriana A Pacheco, Nuria N Lanzagorta, Humberto H Nicolini, Henriette H Raventós, and Michael A MA Escamilla

Arch Gen Psychiatry 67(2):168-77 (2010) PMID 20124116

Although genetic influences on bipolar disorder are well established, localization of genes that predispose to the illness has proven difficult. Given that genes predisposing to bipolar disorder may be transmitted without expression of the categorical clinical phenotype, a strategy for identifying risk genes is to identify and map quantitative intermediate phenotypes or endophenotypes.

DOI: 10.1001/archgenpsychiatry.2009.184
Version: za2963e q8za1 q8zbe q8zc5 q8zd2 q8zed q8zf7 q8zg2
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