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High-dose radioimmunotherapy combined with extracorporeal depletion in a syngeneic rat tumor model: evaluation of toxicity, therapeutic effect, and tumor model.

Linda L Mårtensson, Rune R Nilsson, Tomas T Ohlsson, Hans-Olov HO Sjögren, Sven-Erik SE Strand, and Jan J Tennvall

Cancer 116(4 Suppl):1043-52 (2010) PMID 20127949

The aim of the current study was to investigate the possibility of increasing the maximal tolerated dose (MTD) of a tumor-selective radiolabeled antibody when radioimmunotherapy (RIT) is combined with extracorporeal depletion of radioimmunoconjugates from the circulation. Furthermore, the authors evaluated whether this increase in dose improved the therapeutic effect on solid manifest tumors in an immunocompetent animal model.

DOI: 10.1002/cncr.24791
Version: za2963e q8za0 q8zbd q8zc7 q8zdd q8zea q8zff q8zg7

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