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Codd V. Common variants near TERC are associated with mean telomere length. 42:197 (2010)

We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in...

1061-4036

42

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197-199

Nature Genetics | Brief Communication Common variants near TERC are associated with mean telomere length * Veryan Codd1, 10 Search for this author in: * NPG journals * PubMed * Google Scholar * Massimo Mangino2, 10 Search for this author in: * NPG journals * PubMed * Google Scholar * Pim van der Harst1, 3, 10 Search for this author in: * NPG journals * PubMed * Google Scholar * Peter S Braund1 Search for this author in: * NPG journals * PubMed * Google Scholar * Michael Kaiser1 Search for this author in: * NPG journals * PubMed * Google Scholar * Alan J Beveridge1 Search for this author in: * NPG journals * PubMed * Google Scholar * Suzanne Rafelt1 Search for this author in: * NPG journals * PubMed * Google Scholar * Jasbir Moore1 Search for this author in: * NPG journals * PubMed * Google Scholar * Chris Nelson1 Search for this author in: * NPG journals * PubMed * Google Scholar * Nicole Soranzo2, 4 Search for this author in: * NPG journals * PubMed * Google Scholar * Guangju Zhai2 Search for this author in: * NPG journals * PubMed * Google Scholar * Ana M Valdes2 Search for this author in: * NPG journals * PubMed * Google Scholar * Hannah Blackburn4 Search for this author in: * NPG journals * PubMed * Google Scholar * Irene Mateo Leach3 Search for this author in: * NPG journals * PubMed * Google Scholar * Rudolf A de Boer3 Search for this author in: * NPG journals * PubMed * Google Scholar * Wellcome Trust Case Control Consortium9 * Alison H Goodall1 Search for this author in: * NPG journals * PubMed * Google Scholar * Willem Ouwehand5 Search for this author in: * NPG journals * PubMed * Google Scholar * Dirk J van Veldhuisen3 Search for this author in: * NPG journals * PubMed * Google Scholar * Wiek H van Gilst3 Search for this author in: * NPG journals * PubMed * Google Scholar * Gerjan Navis6 Search for this author in: * NPG journals * PubMed * Google Scholar * Paul R Burton7 Search for this author in: * NPG journals * PubMed * Google Scholar * Martin D Tobin7 Search for this author in: * NPG journals * PubMed * Google Scholar * Alistair S Hall8 Search for this author in: * NPG journals * PubMed * Google Scholar * John R Thompson7 Search for this author in: * NPG journals * PubMed * Google Scholar * Tim Spector2, 10 Search for this author in: * NPG journals * PubMed * Google Scholar * Nilesh J Samani1, 10 Search for this author in: * NPG journals * PubMed * Google Scholar * Affiliations * Contributions * Corresponding authorJournal name:Nature GeneticsVolume:42,Pages:197–199Year published:(2010)DOI:doi:10.1038/ng.532 Article tools * Full text * 日本語要約 * Email * Download PDF * Download citation * Order reprints * Rights and permissions * Share/bookmark * Connotea * CiteULike * Facebook * Twitter * Delicious * Digg We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 × 10−14) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an ~75-base-pair reduction in mean telomere length, equivalent to ~3.6 years of age-related telomere-length attrition. View full text Author information * Author information * Supplementary information Primary authors * These authors contributed equally to this work. * Veryan Codd, * Massimo Mangino, * Pim van der Harst, * Tim Spector & * Nilesh J Samani Affiliations * Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK. * Veryan Codd, * Pim van der Harst, * Peter S Braund, * Michael Kaiser, * Alan J Beveridge, * Suzanne Rafelt, * Jasbir Moore, * Chris Nelson, * Alison H Goodall & * Nilesh J Samani * Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. * Massimo Mangino, * Nicole Soranzo, * Guangju Zhai, * Ana M Valdes & * Tim Spector * Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. * Pim van der Harst, * Irene Mateo Leach, * Rudolf A de Boer, * Dirk J van Veldhuisen & * Wiek H van Gilst * Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK. * Nicole Soranzo & * Hannah Blackburn * Department of Hematology, University of Cambridge, Cambridge, UK. * Willem Ouwehand * Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. * Gerjan Navis * Departments of Health Sciences and Genetics, University of Leicester, Leicester, UK. * Paul R Burton, * Martin D Tobin & * John R Thompson * Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK. * Alistair S Hall * A full list of members is provided is provided in the Supplementary Note. * Wellcome Trust Case Control Consortium Consortia * Wellcome Trust Case Control Consortium Contributions N.J.S. and T.S. conceived the study. V.C., M.M. and P.v.d.H. designed the laboratory work and conducted the analyses. V.C., P.S.B., M.K., J.M., I.M.L. and R.A.d.B. undertook the laboratory work. A.J.B. provided bioinformatics support and S.R., C.N. and N.S. undertook statistical support. A.S.H. and N.J.S. recruited and provided samples and data from the BHF Family Heart Study; W.T.C.C.C. and W.O. from the UKBS samples; A.H.G., P.R.B., M.D.T. and N.J.S. from the GRAPHIC study; G.Z., A.M.V., H.B. and T.S. from the TwinsUK study; and D.J.v.V., W.H.v.G. and G.N. from the PREVEND Study. J.R.T. oversaw the statistical analysis. The paper was written by V.C., M.M. and N.J.S. All authors contributed to the final version of the manuscript. Competing financial interests The authors declare no competing financial interests. Corresponding author Correspondence to: * Nilesh J Samani (njs@le.ac.uk) Supplementary information * Author information * Supplementary information PDF files * Supplementary Text and Figures (964K) Supplementary Figure 1, Supplementary Tables 1–5, Supplementary Methods and Supplementary Note Additional data