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Advances in the treatment of neurodegenerative disorders employing nanotechnology.

Girish G Modi, Viness V Pillay, and Yahya E YE Choonara

Ann N Y Acad Sci (2010) PMID 20146696

Due to limitations posed by the restrictive blood-brain barrier, conventional drug delivery systems do not provide adequate cyto-architecture restoration and connection patterns that are essential for functional recovery in neurodegenerative disorders (NDs). Nanotechnology employs engineered materials or devices that interact with biological systems at a molecular level and could revolutionize the treatment of NDs by stimulating, responding to, and interacting with target sites to induce physiological responses while minimizing side effects. This review provides a concise discussion of the current applications of nano-enabled drug-delivery systems for the treatment of NDs, in particular Alzheimer's and Parkinson's diseases, and explores the future applications of nanotechnology in clinical neuroscience to develop innovative therapeutic modalities for the treatment of NDs.

DOI: 10.1111/j.1749-6632.2009.05108.x
Version: za2963e q8zad q8zb2 q8zcb q8zd5 q8ze9 q8zfe q8zgf

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