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The Dance of the Perivascular and Endothelial Cells: Mechanisms of Brain Response to Immune Signaling

Clifford B CB Saper

Neuron 65(1):3 (2010) PMID 20152108

The mechanisms underlying the brain response to systemic inflammation remain unclear. In this issue of Neuron, Serrats and colleagues demonstrate that two cell types that produce prostaglandins that act on the brain, perivascular and endothelial cells, have an unexpectedly complex interaction in regulating the timing and types of brain responses that occur.

Copyright © 2010 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.neuron.2009.12.029
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