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Discovery of Novel Transcriptional and Epigenetic Targets in APL by Global ChIP Analyses: Emerging Opportunity and Challenge

Jan-Henrik Mikesch, Hinrich Gronemeyer, and Chi Wai Eric So

Cancer Cell 17(2):3 (2010) PMID 20159604

Identifying transcriptional program(s) deregulated by oncoproteins is key to understanding the molecular basis of the disease. In this issue of Cancer Cell, two studies by Martens et al. and Wang et al. provide global blueprints for transcriptional targets and epigenetic modifications mediated by PML-RAR@a in acute promyelocytic leukemia.

Copyright © 2010 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.ccr.2010.01.012
Version: za2963e q8za3 q8zb2 q8zc9 q8zdd q8zeb q8zfd q8zga

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