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Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

Sze Yinn SY Wong, Qing Q Li, Jovana J Veselinovic, Byeong-Su BS Kim, Alexander M AM Klibanov, and Paula T PT Hammond

Biomaterials 31(14):9 (2010) PMID 20163855

In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.

Copyright © 2010 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.biomaterials.2010.01.119
Version: za2963e q8zac q8zb7 q8zcb q8zd4 q8ze3 q8zff q8zg1

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