Advanced search×

Klk8, a multifunctional protease in the brain and skin: analysis of knockout mice.

Shigetaka S Yoshida

Biol Chem 391(4):375-80 (2010) PMID 20180635

Klk8 is a tryptic serine protease with limited substrate specificity. Klk8 mRNA is expressed in many developing organs, whereas its expression is confined to limited regions, including the hippocampus, in adults. In the hippocampus, Klk8 is involved in activity-dependent synaptic changes such as long-term potentiation, which was found to be suppressed in Klk8 knockout (KO) mice. Oligodendrocytes only expressed Klk8 mRNA after injury to the central nervous system. The epidermis of the skin is one of the tissues that exhibits a high level of KLK8 expression. Klk8 might be involved in desquamation through the degradation of adhesive molecules that connect layers of the epidermis. Klk8 might thus be involved in tissue development and rearrangement.

DOI: 10.1515/BC.2010.034
Version: za2963e q8za2 q8zb9 q8zc8 q8zd1 q8ze4 q8zf8 q8zgb
Buy PDF

Similar articles you may find interesting…

  1. A dynamic flow chamber-based adhesion assay to assess canine platelet-matrix interactions in vitro.
    Annika Ferkau, Silke Ecklebe, and Reinhard Mischke

    Vet Clin Pathol (2013) PMID 23627964

    This study indicates the need to carefully select collagen type and concentration to assess canine thrombus formation in a dynamic flow chamber. The established method should be a useful tool to determine changes in platelet-matrix interactions as an indicator of platelet activation or platelet dysf...
    Buy PDF
  2. Dietary and Plant Polyphenols Exert Neuroprotective Effects and Improve Cognitive Function in Cerebral Ischemia.
    Kiran S Panickar and Saebyeol Jang

    Recent Pat Food Nutr Agric (2013) PMID 23621667

    Cerebral ischemia is caused by an interruption of blood flow to the brain which generally leads to irreversible brain damage. Ischemic injury is associated with vascular leakage, inflammation, tissue injury, and cell death. Cellular changes associated with ischemia include impairment...
    Buy PDF
  3. Geminivirus protein structure and function.
    Vincent N Fondong

    Mol Plant Pathol (2013) PMID 23615043

    Geminiviruses are a family of plant viruses that cause economically important plant diseases worldwide. These viruses have circular single-stranded DNA genomes and four to eight genes that are expressed from both strands of the double-stranded DNA replicative intermediate. The transc...
    Buy PDF