Advanced search×

Examining Braak's hypothesis by imaging Parkinson's disease.

David J Brooks

Mov Disord 25(S1):S83-8 (2010) PMID 20187242

In this review, in vivo patterns of structural, metabolic, and neurotransmitter binding changes revealed by imaging in both symptomatic Parkinson's disease (PD) and at-risk subjects are compared with those predicted at different Braak stages. It is concluded that the dysfunction revealed by imaging in PD is only partially in line with the sequential ascending topography of Lewy body pathology reported by Braak, suggesting that neurons in different brain regions are likely to be selectively vulnerable to the presence of intracellular synuclein aggregates.

DOI: 10.1002/mds.22720
Version: za2963e q8zab q8zb0 q8zcf q8zd9 q8zea q8zfb q8zge

Similar articles you may find interesting…

  1. Evidence in favor of Braak staging of Parkinson's disease.
    Dennis W Dickson, Hirotake Uchikado, ... Yoshio Tsuboi

    Mov Disord 25(S1):S78-82 (2010) PMID 20187227

    We studied the density and distribution of LBs with alpha-synuclein immunohistochemistry in normal elderly with incidental LBs (N = 12); progressive supranuclear palsy (PSP) with incidental LBs (N = 18); Lewy body disease (LBD) with minimal or no Alzheimer type pathology (N = 52); LBD with concomita...
  2. Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain
    J E Simpson, P G Ince, ... MRC Cognitive Function and Ageing Neuropathology Study Group

    Neurobiol Aging 31(4):13 (2010) PMID 18586353

    We sought to define the detailed cellular pathology of astrocytes, the extent of population variation and the relationship to Alzheimer-type changes in a population-based cohort. Three staining patterns were associated with GFAP and excitatory amino acid transporter 2 (EAAT2): minimal, moderate or e...