Advanced search×

Nanostructured lipid carriers (NLC) on the basis of Siberian pine (Pinus sibirica) seed oil.

E S ES Averina, G G Seewald, R H RH Müller, L D LD Radnaeva, and D V DV Popov

Pharmazie 65(1):25-31 (2010) PMID 20187575

Nanostructured lipid carriers (NLC) are new drug systems composed of physiological lipid materials. The possibility of including different types of lipids into the NLC structure revealed the wide prospects for using biologically active natural oils for the development of the cutaneous preparations. In this study the formulation parameters of NLC on the basis of Siberian pine seed oil were evaluated including concentration of lipids, types of surfactants and storage conditions (4 degrees C, 20 degrees C, 40 degrees C). Size distribution and storage stability of formulations produced by hot high pressure homogenisation were investigated by laser diffractometry and photon correlation spectroscopy. The NLC were characterised by their melting behaviour using differential scanning calorimetry. The obtained data indicated the high physical stability of the developed NLC formulations.

Version: za2963e q8zae q8zb3 q8zca q8zdc q8ze6 q8zf1 q8zg2

Similar articles you may find interesting…

  1. Effects of acute exposure of alpha 1- and alpha 2-adrenoreceptor agonist or antagonist on capsaicin-evoked substance P release from dorsal r...
    Huaxiang H Liu, Huicui H Gong, ... Zhenzhong Z Li

    Pharmazie 65(1):47-50 (2010) PMID 20187578

    Peripheral alpha-adrenoceptors are involved in mediating neurogenic inflammation. To characterize the effects of acute administration of selective alpha adrenoreceptor agonists or antagonists on capsaicin-evoked substance P (SP) release from dorsal root ganglion (DRG) neurons, dissociated cultured D...
  2. Physical and chemical stability of nanostructured lipid drug carriers (NLC) based on natural lipids from Baikal region (Siberia, Russia).
    E S Averina, R H Müller, ... L D Radnaeva

    Pharmazie 66(5):348-56 (2011) PMID 21699068

    At the turn of the millennium, a new generation of lipid nanoparticles for pharmacology was developed, nanostructured lipid carriers (NLC). The features of NLC structure which allow the inclusion of natural biologically active lipids in the NLC matrix open a wide prospect for the creation of high per...
  3. Enhanced accumulation of low-molecular-weight chitosan in kidneys: a study on the influence of N-acetylation of chitosan on the renal target...
    Zhi-xiang ZX Yuan, Jing-jing JJ Li, ... Zhi-rong ZR Zhang

    J Drug Target 19(7):540-51 (2011) PMID 21767121

    HECs-10 exhibited the highest binding affinity and uptake capacity to MDCK cells, expressing the megalin receptor. Additionally, cytotoxicity assay showed that there were no obvious effects of HECs on the viability of L929 and MDCK cells. Consistent with the cellular uptake study, it was shown in vi...