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Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives

Ozair O Alam, Pooja P Mullick, S P SP Verma, Sadaf J SJ Gilani, Suroor A SA Khan, Nadeem N Siddiqui, and Waquar W Ahsan

Eur J Med Chem 45(6):6 (2010) PMID 20211511

A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.

Copyright © 2010 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.ejmech.2010.02.031
Version: za2963e q8zaf q8zb9 q8zcb q8zdb q8zec q8zf4 q8zg7

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