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Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake.

Jong Hyun JH Kim, Ji-Man JM Park, Kyungmoo K Yea, Hyun Wook HW Kim, Pann-Ghill PG Suh, and Sung Ho SH Ryu

PLoS One 5(3):e9600 (2010) PMID 20231899

Glucose homeostasis is maintained by a balance between hepatic glucose production and peripheral glucose utilization. In skeletal muscle cells, glucose utilization is primarily regulated by glucose uptake. Deprivation of cellular energy induces the activation of regulatory proteins and thus glucose uptake. AMP-activated protein kinase (AMPK) is known to play a significant role in the regulation of energy balances. However, the mechanisms related to the AMPK-mediated control of glucose uptake have yet to be elucidated.

DOI: 10.1371/journal.pone.0009600
Version: za2963e q8za7 q8zbe q8zc3 q8zdc q8ze9 q8zf5 q8zg5
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