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Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples.

P L PL Urban, A A Amantonico, S R SR Fagerer, P P Gehrig, and R R Zenobi

Chem Commun (London) 46(13):2212-4 (2010) PMID 20234909

We report a sensitive method for selective detection of target metabolites from the central metabolic pathway by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS), in which the MS signal is enhanced by up to three orders of magnitude in the course of in situ enzymatic amplification.

DOI: 10.1039/b925433a
Version: za2963e q8zaa q8zb1 q8zc7 q8zd3 q8ze7 q8zf8 q8zgf

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