Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples.
Chem Commun (London) 46(13):2212-4 (2010) PMID 20234909
We report a sensitive method for selective detection of target metabolites from the central metabolic pathway by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS), in which the MS signal is enhanced by up to three orders of magnitude in the course of in situ enzymatic amplification.
DOI: 10.1039/b925433a
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