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In vivo MRI assessment of permanent middle cerebral artery occlusion by electrocoagulation: pitfalls of procedure.

Fabien Chauveau, Samir Moucharrafie, Marlène Wiart, Jean-Christophe Brisset, Yves Berthezène, Norbert Nighoghossian, and Tae-Hee Cho

Exp Transl Stroke Med 2(1):4 (2010) PMID 20298536

Permanent middle cerebral artery (MCA) occlusion (pMCAO) by electrocoagulation is a commonly used model but with potential traumatic lesions. Early MRI monitoring may assess pMCAO for non-specific brain damage. The surgical steps of pMCAO were evaluated for traumatic cerebral injury in 22 Swiss mice using diffusion and T2-weighted MRI (7T) performed within 1 h and 24 h after surgery. Temporal muscle cauterization without MCA occlusion produced an early T2 hyperintensity mimicking an infarct. No lesion was visible after temporal muscle incision or craniotomy. Early MRI monitoring is useful to identify non-specific brain injury that could hamper neuroprotective drugs assessment.

DOI: 10.1186/2040-7378-2-4
Version: za2963e q8za9 q8zb5 q8zcc q8zda q8ze0 q8zfc q8zg0
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