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Ircinialactams: Subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

Bioorganic & Medicinal Chemistry 18(8):2912 (2010) PMID 20346682

Screening an extract library of marine invertebrates yielded new glycinyl lactam sesterterpenes with potent and subunit selective modulatory properties against α1 and α3 glycine receptor (GlyR) chloride channels isoforms.

DOI: 10.1016/j.bmc.2010.03.002