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NO-Xplode: a case of supplement-associated ischemic colitis.

Charles D CD Magee, Fouad J FJ Moawad, and Frank F Moses

Mil Med 175(3):202-5 (2010) PMID 20358712

The most common cause of ischemic colitis (IC) is a sudden and transient reduction in splanchnic perfusion. In the younger population, medications are an increasingly recognized cause of ischemic bowel disease. Over-the-counter supplements may also lead to the development of ischemic colitis through similar effects. We present a case of ischemic colitis in a 42-year-old active duty service member after using the performance-enhancing supplement, NO-Xplode. In this report, we review the pharmacology of this supplement and its proposed mechanism of injury.

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