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Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock.

Taccone FS, Laterre PF, Spapen H, Dugernier T, Delattre I, Layeux B, De Backer D, Wittebole X, Wallemacq P, Vincent JL, and Jacobs F

Audio, Transactions of the IRE Professional ... 14(2):R53 (2010) PMID 20370907 PMCID PMC2887170

It has been proposed that doses of amikacin of >15 mg/kg should be used in conditions associated with an increased volume of distribution (Vd), such as severe sepsis and septic shock. The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients.

DOI: 10.1186/cc8945
Version: za2963e q8zad q8zb7 q8zc0 q8zdc q8ze8 q8zff q8zgc
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