Advanced search×

Revisiting the loading dose of amikacin for patients with severe sepsis and septic shock.

Taccone FS, Laterre PF, Spapen H, Dugernier T, Delattre I, Layeux B, De Backer D, Wittebole X, Wallemacq P, Vincent JL, and Jacobs F

Audio, Transactions of the IRE Professional ... 14(2):R53 (2010) PMID 20370907 PMCID PMC2887170

It has been proposed that doses of amikacin of >15 mg/kg should be used in conditions associated with an increased volume of distribution (Vd), such as severe sepsis and septic shock. The primary aim of this study was to determine whether 25 mg/kg (total body weight) of amikacin is an adequate loading dose for these patients.

DOI: 10.1186/cc8945
Version: za2963e q8zad q8zb7 q8zc0 q8zdc q8ze8 q8zff q8zgc
View PDF

Similar articles you may find interesting…

  1. Insufficient beta-lactam concentrations in the early phase of severe sepsis and septic shock.
    Fabio Silvio Taccone, Pierre-Francois Laterre, ... Frederique Jacobs

    Crit Care 14(4):R126 (2010) PMID 20594297 PMCID PMC2945087

    Serum concentrations of the antibiotic after the first dose were acceptable only for meropenem. Standard dosage regimens for piperacillin-tazobactam, ceftazidime and cefepime may, therefore, be insufficient to empirically cover less susceptible pathogens in the early phase of severe sepsis and septi...
    View PDF
  2. Infection in critically ill patients: clinical impact and management.
    Jean-Louis JL Vincent and Frédérique F Jacobs

    Curr Opin Infect Dis 16(4):309-13 (2003) PMID 12861083

    New definitions of sepsis, including a grading system, similar to the tumor, node, metastasis system for cancer, have been suggested and are being developed. In terms of epidemiology, sepsis remains an important cause of morbidity and mortality among the critically ill, but the last couple of years...
  3. Human herpesvirus-6 infection after lung and heart-lung transplantation: a prospective longitudinal study.
    Frédérique F Jacobs, Christiane C Knoop, ...

    Transplantation 75(12):1996-2001 (2003) PMID 12829900

    HHV-6 infection occurred in 20 (66%) patients after a median delay of 18 days after transplantation. The virus was detected by polymerase chain reaction or culture, or both, in 15.7 % of blood specimens, in 14.5% of bronchoalveolar lavage fluids, and in many organs at postmortem examination; it was...