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Human endothelial dysfunction: EDRFs.

Andreas J Flammer and Thomas F Lüscher

Pflugers Arch 459(6):1005-13 (2010) PMID 20383717

Since the detection of nitric oxide two and a half decades ago, there has been an incredible boost in endothelial function research, which is fascinating the research community. Physiologically, endothelial cells synthesize a number of vasoactive substances. In particular, several endothelium-derived relaxing factors (EDRFs) have been characterized, whereby nitric oxide is the most important. In humans, endothelial dysfunction is one of the first clinically detectable alterations in the development of atherosclerosis and is characterized by an imbalance in the release of vasoactive substances. Thus, it is the aim of this article to give an overview about endothelial function in humans, to summarize the different possibilities to assess endothelial function in this species, and to give an overview of the role of EDRFs in different cardiovascular diseases.

DOI: 10.1007/s00424-010-0822-4
Version: za2963e q8za4 q8zb0 q8zc7 q8zd3 q8ze0 q8zfb q8zg2
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