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Thrombophilic risk factors and peripheral arterial disease severity.

Michelangelo M Sartori, Elisabetta E Favaretto, Cristina C Legnani, Michela M Cini, Eleonora E Conti, Alfio A Amato, and Gualtiero G Palareti

Thromb Haemost 104(1):71-7 (2010) PMID 20390230

Few data are available on thrombophilic risk factors and progression of atherosclerotic peripheral arterial disease (PAD). Thrombophilic alterations can be an aggravating factor when arterial stenoses are present. In a cross-sectional study, we evaluated the presence of the thrombophilic factors fibrinogen, homocysteine, factor (F)VIII, lupus anticoagulant (LAC), FII G20210A, and FV R506Q mutations in 181 patients with PAD at Fontaine's stage II (claudication), in 110 patients with critical limb ischaemia (CLI), and in 210 controls. Fibrinogen was higher in patients with CLI vs. those with claudication and controls (427.9 +/- 10.5 vs. 373.1 +/- 5.2 vs. 348.9 +/- 7.0 p=0.001, respectively). Homocysteine and FVIII were higher in patients with PAD than in controls, but were similar in patients with CLI and claudication. The prevalence of LAC increased in patients with CLI vs. those with claudication and controls (21.4% vs. 7.8% vs. 5.2% p

DOI: 10.1160/TH09-11-0772
Version: za2963e q8za6 q8zb9 q8zcb q8zd0 q8ze4 q8zf6 q8zg3

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