Advanced search×

Baculovirus as vaccine vectors.

Selvaraj S Madhan, Mookkan M Prabakaran, and Jimmy J Kwang

Curr Gene Ther 10(3):201-13 (2010) PMID 20394572

Application of viral vectors derived from human viruses to mediate immune response in animals and humans has been greatly hampered by the problems associated with pre-existing immunity and associated toxicities. Among few non-human viral vectors, baculovirus has now evolved as a novel tool for vaccine vector development. With broad tissue tropism and expanded bio-safety profile suitably supplemented with intrinsic immunostimulatory properties, baculovirus has now attained a niche position in the arena of vaccine development. Recombinant envelope-modified baculovirus equipped with novel shuttle promoters for in vivo transduction has shown promising results in several animal models. Baculovirus mediated induction of systemic and mucosal immune responses through intranasal or oral administration has now open an entirely new way for the development of new generation vaccines. Gaining additional insight into the baculovirus biology and its interaction with non-native hosts will certainly promote this human-friendly virus as a potential vector for clinical applications.

Version: za2963e q8za0 q8zb5 q8zcc q8zd2 q8ze1 q8zf9 q8zgc
Buy PDF

Similar articles you may find interesting…

  1. Molecular epidemiological survey of Theileria orientalis in Thua Thien Hue Province, Vietnam.
    Altangerel A Khukhuu, Dinh Thi Bich DT Lan, ... Naoaki N Yokoyama

    J Vet Med Sci 73(5):701-5 (2011) PMID 21187678

    We report the findings of a molecular epidemiological survey of T. orientalis in 94 Vietnamese yellow cattle, 43 water buffaloes, 21 sheep, 21 goats and 85 blood-sucking ticks of cattle in the Thua Thien Hue province of Vietnam. The major piroplasm surface protein (MPSP) gene of T. orientalis was de...
    Buy PDF
  2. A new insect cell line from the longicorn beetle Plagionotus christophi (Coleoptera: Cerambycidae)
    Keita Hoshino, Mami Hirose, and Kikuo Iwabuchi

    In Vitro Cell Dev Biol Anim 45(1-2):19-22 (2009) PMID 18946707

    We have established a continuous cell line from the fat body tissue of the longicorn beetle Plagionotus christophi. The cells have been serially subcultured in MGM450 medium, and the line has been designated as PC-1. The cells were grown in suspension and comprise largely flattened spindle- or oval-...
    Buy PDF
  3. Survey of Babesia microti infection in field rodents in Japan: records of the Kobe-type in new foci and findings of a new type related to th...
    Atsuko A Saito-Ito, Midori M Kasahara, ... Nobuhiro N Takada

    Microbiol Immunol 51(1):15-24 (2007) PMID 17237595

    Of 247 rodents comprising 5 genera and 7 species collected at 17 sites throughout Japan from 2003 to 2005, Babesia microti was detected microscopically and by polymerase chain reaction (PCR) in 36 rodents comprising 2 genera and 3 species from 12 sites. Based on the analysis of small subunit ribosom...
    Buy PDF