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Human islet cell implants in a nude rat model of diabetes survive better in omentum than in liver with a positive influence of beta cell number and purity.

D Jacobs-Tulleneers-Thevissen, K Bartholomeus, K Suenens, I Vermeulen, Z Ling, K H Hellemans, P In't Veld, M Pipeleers-Marichal, and D Pipeleers

Diabetologia 53(8):1690-9 (2010) PMID 20397000

Intraportal human islet cell grafts do not consistently and sustainably induce insulin-independency in type 1 diabetic patients. The reasons for losses in donor cells are difficult to assess in patients. This study in streptozotocin-diabetic nude rats examines whether outcome is better in an extra-hepatic site such as omentum.

DOI: 10.1007/s00125-010-1721-0
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