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The sequence and phylogenesis of the ?-globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries musimon) and Cyprus mouflon (Ovis aries ophion).

Monica M Pirastru, Chiara C Multineddu, Paolo P Mereu, Mara M Sannai, El Said el S El Sherbini, Eleftherios E Hadjisterkotis, Andràs A Nàhlik, Paul P Franceschi, Laura L Manca, and Bruno B Masala

Comp Biochem Physiol Part D Genomics Prote... 4(3):168-73 (2009) PMID 20403763

In order to investigate the polymorphism of ?-globin chain of hemoglobin amongst caprines, the linked (I)? and (II)? globin genes of Barbary sheep (Ammotragus lervia), goat (Capra hircus), European mouflon (Ovis aries musimon), and Cyprus mouflon (Ovis aries ophion) were completely sequenced, including the 5? and 3? untranslated regions. European and Cyprus mouflons, which do not show polymorphic ? globin chains, had almost identical ? globin genes, whereas Barbary sheep exhibit two different chains encoded by two nonallelic genes. Four different ? genes were observed and sequenced in goat, validating previous observations of the existence of allelic and nonallelic polymorphism. As in other vertebrates, interchromosomal gene conversion appears to be responsible for such polymorphism. Evaluation of nucleotide sequences at the level of molecular evolution of the (I)?-globin gene family in the caprine taxa suggests a closer relationship between the genus Ammotragus and Capra. Molecular clock estimates suggest sheep-mouflon, goat-aoudad, and ancestor-caprine divergences of 2.8, 5.7, and 7.1 MYBP, respectively.

Copyright © 2009 Elsevier Ltd. All rights reserved.

DOI: 10.1016/j.cbd.2009.02.002
Version: za2963e q8za7 q8zbe q8zce q8zd1 q8zed q8zf2 q8zg7

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