The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors.
Audio, Transactions of the IRE Profession... 11(5):373-84 (2010) PMID 20404851
The discovery of Toll-like receptors (TLRs) as components that recognize conserved structures in pathogens has greatly advanced understanding of how the body senses pathogen invasion, triggers innate immune responses and primes antigen-specific adaptive immunity. Although TLRs are critical for host defense, it has become apparent that loss of negative regulation of TLR signaling, as well as recognition of self molecules by TLRs, are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, it is now clear that the interaction between TLRs and recently identified cytosolic innate immune sensors is crucial for mounting effective immune responses. Here we describe the recent advances that have been made by research into the role of TLR biology in host defense and disease.
DOI: 10.1038/ni.1863Version: za2963e q8za7 q8zb3 q8zc7 q8zde q8ze8 q8zf2 q8zg4
