Despite increasing knowledge of cellular and molecular mechanisms determining the success or failure of peripheral nerve regeneration, no effective treatments for peripheral nerve injury exist. Newly developed and validated approaches for precise numerical assessment of motor deficits have recently allowed testing of novel strategies in experimental animals. One of these approaches is the daily manual stimulation of the denervated musculature. This treatment is effective in cases of cranial nerve lesions with preservation of the sensory input (facial or hypoglossal nerve) and has the potential of direct translation in clinical settings. However, manual stimulation appears to be ineffective for the treatment of mixed peripheral nerve injuries. Generally, no long-term improvement of functional recovery is achieved by electrical stimulation in rodents. While short-term post-traumatic stimulation of the proximal nerve stump has no negative effects, direct electrical stimulation of the muscle during the period of de- and reinnervation appears to hinder muscle fibre reinnervation. Finally, experimental evidence suggests that application of peptides known as glycomimetics, which mimic functional properties of carbohydrate molecules, may provide significant benefits after injuries of mixed peripheral nerves.
The analysis of main components confirmed dimensionality patterns that were comparable between the original and adapted versions. In two domains of the instrument, critical comments and emotional over-involvement had moderate and significant correlations, respectively, with Antonovsky's Sense of Coh...
We study the
Large-scale diffuse X-ray emission associated with the massive spiral galaxy
NGC266. Using ROSAT and Chandra X-ray observations we argue that the diffuse
Emission extends to at least ~70 kpc, whereas the bulk of the stellar light is
Confined to within ~25 kpc. Based on X-ray hardness ra...
We present CCD Washington CT1 photometry to T1 ~ 23 in
The fields of twenty-three mostly unstudied clusters located in the inner disc
And outer regions of the LMC. We estimated cluster radii from star counts.
Using the cluster Washington (T1,C-T1) colour-magnitude diagrams, statistically
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