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[Tuberous sclerosis: evaluation of myofibroblasts in cutaneous angiofibromas - case report].

Erick Gomes EG Perez, Lívia Ribeiro LR Paranaíba, Paulo Rogério PR Bonan, Julian Miranda JM Orsi Júnior, Adriano Macedo de AM Oliveira, and Hercílio H Martelli Júnior

An Bras Dermatol 85(1):84-8 (2010) PMID 20464093

Tuberous sclerosis is a rare autosomal dominant disorder. Myofibroblasts are cells with a hybrid phenotype between fibroblasts and smooth muscle cells. The objective of this study is to describe clinical and histopathological characteristics of tuberous sclerosis and to conduct an immunohistochemical evaluation of myofibroblasts in cutaneous angiofibromas present in this condition. Lesion sections removed were stained with hematoxylin-eosin and Masson's trichrome. Immunohistochemistry against alpha-SMA was done to determine the presence of myofibroblasts, and the reaction was negative. Since alpha-SMA is a specific marker for myofibroblasts, this result suggests that myofibroblasts are not involved in cutaneous angiofibromas present in the tuberous sclerosis case reported.

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