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Results from a phase I clinical study of the novel Ii-Key/HER-2/neu(776-790) hybrid peptide vaccine in patients with prostate cancer.

Sonia A SA Perez, Nikoletta L NL Kallinteris, Stratos S Bisias, Panagiotis K PK Tzonis, Katerina K Georgakopoulou, Marighoula M Varla-Leftherioti, Michael M Papamichail, Anastasios A Thanos, Eric E von Hofe, and Constantin N CN Baxevanis

Clin Cancer Res 16(13):3495-506 (2010) PMID 20466887

Active immunotherapy is emerging as a potential therapeutic approach for prostate cancer. We conducted the first phase I trial of an Ii-Key/HER-2/neu(776-790) hybrid peptide vaccine (AE37) with recombinant granulocyte macrophage colony-stimulating factor as adjuvant in patients with HER-2/neu(+) prostate cancer. The primary end points of the study were to evaluate toxicity and monitor patients' immune responses to the vaccine.

DOI: 10.1158/1078-0432.CCR-10-0085
Version: za2963e q8zad q8zb2 q8zce q8zd5 q8zec q8zf4 q8zg2

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