Advanced search×

Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E - J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata.

David M DM Pinkerton, Martin G MG Banwell, Mary J MJ Garson, Naresh N Kumar, Manoel Odorico MO de Moraes, Bruno C BC Cavalcanti, Francisco W A FW Barros, and Cláudia C Pessoa

Chem Biodivers 7(5):1311-24 (2010) PMID 20491087

In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non-selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis-inducing effects.

DOI: 10.1002/cbdv.201000030
Version: za2963e q8za9 q8zb6 q8zc7 q8zde q8ze4 q8zfe q8zgc

Similar articles you may find interesting…

  1. Phenolic content and in vitro inhibitory effects on oxidation and protein glycation of some Thai medicinal plants.
    Nasapon N Povichit, Ampai A Phrutivorapongkul, ... Pimporn P Leelapornpisid

    Pak J Pharm Sci 23(4):403-8 (2010) PMID 20884454

    Fifteen medicinal plant extracts were investigated for: total phenolic content and free radical scavenging effect by DPPH and ABTS assays; anti-lipid peroxidation activity by TBARS; and for antiglycation activity. The results revealed that the total phenolic content showed good correlation with free...
  2. Chemical composition of natural colophony from Pinus brutia and comparison with synthetic colophony.
    Ahmet C Gören, Gökhan Bilsel, ... Gülaçti Topçu

    Nat Prod Commun 5(11):1729-32 (2010) PMID 21213968

    The compositions of colophony resins obtained from Pinus brutia Ten trees by three different methods (acid paste, carved hole and scraping) from Ayvacik, Gökova and Kemalpaşa in Turkey were analyzed by capillary GC-MS. The main components were the monoterpenes alpha-pinene, beta-pi...
  3. 17{beta}-Estradiol Accelerates Tumor Onset and Decreases Survival in a Transgenic Mouse Model of Ovarian Cancer.
    Laura A Laviolette, Kenneth Garson, ... Barbara C Vanderhyden

    Endocrinology 151(3):929-938 (2010) PMID 20056833

    Epithelial ovarian cancer is thought to be derived from the ovarian surface epithelium (OSE) but often goes undetected in the early stages, and as a result, the factors that contribute to its initiation and progression remain poorly understood. Epidemiological studies have suggested...