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A double-blind, placebo-controlled trial of four fixed rate infusion regimens of phenylephrine for hemodynamic support during spinal anesthesia for cesarean delivery.

Terrence K TK Allen, Ronald B RB George, William D WD White, Holly A HA Muir, and Ashraf S AS Habib

Anesth Analg 111(5):1221-9 (2010) PMID 20495139

The administration of prophylactic phenylephrine infusions in combination with fluid cohydration significantly reduces the incidence of hypotension in women having cesarean delivery under spinal anesthesia. The ideal dosing regimen for this purpose is not known. In this study, we investigated the dose of phenylephrine that, when administered as a prophylactic fixed rate infusion, is associated with the least interventions needed to maintain maternal systolic blood pressure (SBP) within 20% of baseline.

DOI: 10.1213/ANE.0b013e3181e1db21
Version: za2963e q8za1 q8zbc q8zc4 q8zd7 q8zea q8zf2 q8zg5

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